Bioinformatic researchers contribute to science through development of innovative methods, and through application of established methods to understand data they and their collaborators generate. Bioconductor (https://bioconductor.org) plays an essential role, providing a way for researchers to share their scientific contributions with a wide audience while encouraging many ‘best practices’ in software development, dissemination, and use. But science and technology change quickly. This talk addresses how R / Bioconductor adapts to challenges like single-cell and spatial genomics, multi-omics, using R with other software languages, containerization, and cloud computing initiatives.